III. Gluconeogenesis

 

 

 

 

The Cori Cycle

 

Irreversible Steps of Glycolysis

 

1. Pyruvate Carboxylase

2. Phosphoenolpyruvate Carboxykinase

 

 

 

 

 

 

 

3. Fructose 1,6-Bisphosphatase

Fructose 1,6-BisP + H2O ---> Fructose 6-P + Pi

 

 

 

4. Glucose 6-Phosphatase

Glucose 6-P + H2O ---> Glucose + Pi

Bypass Reactions of Gluconeogenesis Part III

 

 

Glycolysis, Glucose ---> 2 Pyruvate:

Glucose + 2 ADP + 2 Pi + 2 NAD+ --->

2 Pyruvate + 2 ATP + 2 NADH + 2 H+ + 2 H2O

DG°’ = -20 kcal/mol

 

 

Gluconeogenesis, 2 Pyruvate ---> Glucose:

2 Pyruvate + 4 ATP + 2 GTP + 2 NADH + 6 H2O --->

Glucose + 4 ADP + 2 GDP + 6 Pi + 2 NAD+ + 2 H+

DG°’ = -9 kcal/mol