Chromatin Structure

Biochemistry 201

Advanced Molecular Biology

January 10, 2000

Doug Brutlag

Chromatin Structure Handout

Chromatin Remodeling Handout

Chromatin Structure Slides

Chromatin Remodeling Slides

(You must use Acrobat Reader to View Handout)

Chromatin Structures

DNA Wrapped in Nucleosome (1DNN)

Histone H1 Globular Region (1HST)

Methanobacter Histone B (1BFM)

Nucleosome Core Particle (1AOI)

Chromatin Structure References

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  2. Bonifer C, Jägle,U and Huber, M C (1997) The Chicken Lysozyme Locus as a Paradigm for the Complex Developmental Regulation of Eukaryotic Gene Loci J. Biol. Chem. 272 (42), 26075-26078
  3. Bonne-Andrea, C., Wong, M. L. and Alberts, B. M. (1990). In vitro replication through nucleosomes without histone displacement. Nature, 343(6260), 719-726.
  4. Felsenfeld, G. (1992). Chromatin as an essential part of the transcriptional mechanism. Nature, 355(6357), 219-224.
  5. Fisher, P. A. (1989). Chromosomes and chromatin structure: the extrachromosomal karyoskeleton. Curr Opin Cell Biol, 1(3), 447-53.
  6. Grunstein, M. (1992). Histones as Regulators of Genes. Scientific American, 267(October), 68-74b.
  7. Igo-Kemenes, T., Horz, W., and Zachau, H. G. (1982). Chromatin. Annual Review of Biochemistry 51, 89-122.
  8. Isenberg, I. (1979). Histones. Annual Review of Biochemistry 48, 159-192.
  9. Kornberg, R. D. (1977). The structure of chromatin. Annual Review of Biochemistry 46, 931-954.
  10. Lewin, B. (1994). Chromatin and gene expression: constant questions, but changing answers. Cell, 79(3), 397-406.
  11. Lohr, D.(1997). Nucleosome Transactions on the Promoters of the Yeast GAL and PHO Genes. J. Biol. Chem. 272 (43) 26795-26798.
  12. Lugar, K, Mader, A. W., Richmond, R. K., Sargent, D. F. & Richmond, T. J. (1997). Crystal structure of the nucleosome core particle at 2.8 Å resolution Nature 389, 251 &endash; 260.
  13. McGhee, J.D. and Felsenfeld, G. (1980). Nucleosome structure. Annual Review of Biochemistry 49, 1115-1156.
  14. Peterson, C. L. and Tamkun, J. W. (1995). The SWI-SNF complex: a chromatin remodeling machine? Trends Biochem Sci, 20(4), 143-6.
  15. Pruss, D., Hayes, J. J. and Wolffe, A. P. (1995). Nucleosomal anatomy--where are the histones? Bioessays, 17(2), 161-70.
  16. Pugh BF, (1992) Diverse transcriptional functions of the multisubunit eukaryotic TFIID complex. J. Biol. Chem. 267, 679-682 (1992)
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  20. van Holde KE, (1992) What happens to nucleosomes during transcription? J. Biol. Chem. 267, 2837-2840 (1992)
  21. van Holde, K. and Zlatanova, J. (1994). Unusual DNA structures, chromatin and transcription. Bioessays, 16(1), 59-68.
  22. van Holde K, (1995) Chromatin higher order structure: chasing a mirage? J. Biol. Chem. 270, 8373-8376 (1995)
  23. Wolffe, A. P. (1994). Nucleosome positioning and modification: chromatin structures that potentiate transcription. Trends Biochem Sci, 19(6), 240-4.
  24. Wolffe, A. P. (1994). The transcription of chromatin templates. Curr Opin Genet Dev, 4(2), 245-54.
  25. Wolffe, A. P. (1994). Transcriptional activation. Switched-on chromatin. Curr Biol, 4(6), 525-8.

Chromatin Remodeling References

  1. Becker, P. B. (1994). The establishment of active promoters in chromatin. Bioessays, 16(8), 541-7.
  2. Bonne-Andrea, C., Wong, M. L. and Alberts, B. M. (1990). In vitro replication through nucleosomes without histone displacement. Nature, 343(6260), 719-726.
  3. Cairns, B. R., Lorch, Y., Li, Y., Zhang, M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Du, J., Laurent, B. and Kornberg, R. D. (1996). RSC, an essential, abundant chromatin-remodeling complex. Cell, 87(7), 1249-60.
  4. Cairns, B.R., Erdjument-Bromage, H., Tempst, P., Winston, F., and Kornberg, R.D. (1998). Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF. Mol. Cell 2, 639-651.
  5. Cairns, B.R. (1998). Chromatin remodeling machines: similar motors, ulterior motives. Trends Biochem. Sci. 23, 20-25
  6. Corona, D. F. V., Längst, G., Clapier, C. R., Bonte, E. J., Ferrari, S., Tamkun, J. W., Becker, P. B. (1999). ISWI Is an ATP-Dependent Nucleosome Remodeling Factor. Molecular Cell 3: 239-245
  7. Felsenfeld, G. (1992). Chromatin as an essential part of the transcriptional mechanism. Nature, 355(6357), 219-224.
  8. Felsenfeld, G., Boyes, J., Chung, J., Clark, D. and Studitsky, V. (1996). Chromatin structure and gene expression. Proc Natl Acad Sci U S A, 93(18), 9384-8.
  9. Felsenfeld, G. (1996). Chromatin Unfolds. Cell 86, 13-19.
  10. Grunstein M. (1997) Molecular model for telomeric heterochromatin in yeast. Curr Opin Cell Biol. 9(3):383-7.
  11. Grunstein, M. (1997). Histone acetylation in chromatin structure and transcription. Nature 389, 349-352 Kadonaga, J. T. (1998) Eukaryotic Transcription: An Interlaced Network of Transcription Factors and Chromatin-Modifying Machines Cell, Vol. 92, 307-313,
  12. Lorch, Y., Cairns, B.R., Zhang, M., and Kornberg, R.D. (1998). Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94, 29-34.
  13. Patterton, D. and Wolffe, A. P. (1996). Developmental roles for chromatin and chromosomal structure. Dev Biol, 173(1), 2-13.
  14. Peterson, C. L., Dingwall, A. and Scott, M. P. (1994). Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement Proc Natl Acad Sci U S A, 91(8), 2905-8.
  15. Peterson, C. L. and Tamkun, J. W. (1995). The SWI-SNF complex: a chromatin remodeling machine? Trends Biochem Sci, 20(4), 143-6.
  16. Phelan, M. L., Sif, S., Narlikar, G. J., Kingston, R. E. (1999). Reconstitution of a Core Chromatin Remodeling Complex from SWI/SNF Subunits. Molecular Cell 3: 247-253
  17. Pruss, D., Hayes, J. J. and Wolffe, A. P. (1995). Nucleosomal anatomy--where are the histones? Bioessays, 17(2), 161-70.
  18. Shibahara, K.-I. and Stillman, B.(1999). Replication-Dependent Marking of DNA by PCNA Facilitates CAF-1-Coupled Inheritance of Chromatin. Cell 96, 575&endash;585.
  19. Smith, S., and Stillman, B. (1989). Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro. Cell 58, 15-25.
  20. Stillman, B. (1986). Chromatin assembly during SV40 DNA replication in vitro. Cell 45, 555-565.
  21. Travers, Andrew (1999) An Engine for Nucleosome Remodeling Minireview Cell, Vol. 96, 311&endash;314.
  22. van Holde, K. and Zlatanova, J. (1994). Unusual DNA structures, chromatin and transcription. Bioessays, 16(1), 59-68.
  23. van Holde, K. and Zlatanova, J. (1995). Chromatin higher order structure: chasing a mirage? J Biol. Chem, 270(15), 8373-6.
  24. Varga-Weisz, et al. (1997) Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. Nature 388, 598 &endash; 602.
  25. Wolffe, A. P. (1994). Nucleosome positioning and modification: chromatin structures that potentiate transcription. Trends Biochem Sci, 19(6), 240-4.
  26. Wolffe, A. P. (1994). The transcription of chromatin templates. Curr Opin Genet Dev, 4(2), 245-54.
  27. Wolffe, A. P. (1994). Transcriptional activation. Switched-on chromatin. Curr Biol., 4(6), 525-8.
  28. Wolffe, A. P. (1996). Chromatin and gene regulation at the onset of embryonic development. Reprod Nutr Dev, 36(6), 581-606.
  29. Wolffe, A. P. and Pruss, D. (1996). Deviant nucleosomes: the functional specialization of chromatin. Trends Genet, 12(2), 58-62.
  30. Wolffe, A. P. and Pruss, D. (1996). Hanging on to histones. Chromatin. Curr Biol, 6(3), 234-7.
  31. Wolffe, A. P. and Pruss, D. (1996). Targeting chromatin disruption: Transcription regulators that acetylate histones. Cell, 84(6), 817-9.