Recent Publications:
Weissman I.L., J. Allison, F.W.
Alt, H. von Boehmer, M.D. Cooper, I. Feller, L.H. Glimcher, D.V. Goeddel, H.
McDevitt, D. Mathis, G. Nossal, R.M. Perlmutter, C.B. Thompson, and D.C.
Wiley. International Benchmarking
of US Immunology Research, National Academy of Sciences, National Academy
Press, 2000.
Weissman I.L. Stem cells: units of development, units of regeneration, and units in
evolution. Invited review, Cell 100: 157-168, 2000.
Domen J., S. Cheshier, and I.L.
Weissman. The role of apoptosis in
the regulation of hematopoietic stem cells: overexpression of BCL-2 increases both their number and
repopulation potential. J. Exp. Med. 191:
253-263, 2000.
Weissman I.L. and N.
Uchida. Hematopoietic stem
cells: biological targets and
therapeutic tools. In: Clinical Bone Marrow and Blood Stem
Cell Transplantation. K Atkinson,
Ed. Cambridge Press, pp. 19-42,
2000.
Weissman I.L. Translating stem and progenitor cell
biology to the clinic: barriers
and opportunities. Invited review,
Science 287: 1442-1446, 2000.
Akashi K, T. Reya, D.
Dalma-Weiszhausz, and I.L. Weissman.
Lymphoid precursors.
Current Opinion in Immunol. 12:
144-150, 2000.
Akashi K, D. Traver, T.
Miyamoto, and I.L. Weissman. A
clonogenic common myeloid progenitor that gives rise to all myeloid lineages.
Nature 404: 193-197, 2000.
Kim S., K. Iizuka, H.L. Aguila, I.L.
Weissman, and W.M. Yokoyama. In
vivo natural killer cell activities revealed by natural killer
cell-deficient mice. PNAS 97:2731-36, 2000.
Nisitani S, A.B.
Satterthwaite, K. Akashi, I.L.
Weissman, O.N. Witte, and M.I. Wahl.
Posttranscriptional regulation of Bruton’s tyrosine kinase
expression in antigen receptor-stimulated splenic B cells. PNAS 97:2737-42, 2000.
Akashi K, L.I. Richie, T.
Miyamoto, W.H. Carr, and I.L. Weissman.
B lymphopoiesis in the thymus.
J. Immunol. 164: 5221-26, 2000.
Negrin RS, K. Atkinson, T.
Leemhuis, E. Hanania, C. Juttner, K. Tierney, W.W. Hu, L.J. Johnston, J.A.
Shizuru, K.E. Stockerl-Goldstein, K.G. Blume, I.L. Weissman, S. Bower, R.
Baynes, R. Dansey, C. Karnes, W. Peters, and J. Klein. Transplantation of highly purified CD34+Thy1+
hematopoietic stem cells in patients with metastatic breast cancer. Biol. Of
Blood and Marrow Transplantation 6:
262-271, 2000.
Laird, D.J., A.W. De Tomaso, M.D.
Cooper, and I.L.Weissman. 50
million years of chordate evolution:
seeking the origins of adaptive immunity. PNAS 97: 6924-6926,
2000.
Miyamoto, T., I.L.Weissman, and
K. Akashi. AML1/ETO-expressing
nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal
translocation. PNAS 97: 7521-7526,
2000.
Lauzon R.J., B. Rinkevich, C.W. Patton, and I.L.Weissman. A morphological study of nonrandom
senescence in a colonial urochordate.
Biol. Bull. 198: 367-378, 2000.
Klug C.A., S. Cheshier, and I.L.
Weissman. Inactivation of a GFP
retrovirus occurs at multiple levels in long-term repopulating stem cells and
their differentiated progeny. Blood
96: 894-901, 2000.
Kondo M., D.C. Scherer, T.
Miyamoto, A.G. King, K. Akashi, K. Sugamura, and I.L. Weissman.
Cell-fate conversion of lymphoid-committed progenitors by instructive
actions of cytokines. Nature 407: 383-386, 2000.
Kina T., K. Ikuta, E. Takayama,
K. Sen Wada, A.S. Majumdar, I.L. Weissman, and Y. Katsura. The monoclonal antibody TER-119
recognizes a molecule associated with glycophorin A and specifically marks the
late stages of murine erythroid lineage.
British J. Hematology 109: 280-287,
2000.
Kondo, M., and I.L.
Weissman. Function of cytokines in
lymphocyte development. In: Lymphoid Organogenesis. F. Melchers, Ed. Springer-Verlag, pp. 59-65, 2000.
Lagasse E., H. Connors, M.
Al-Dhalimy, M. Reitsma, M. Dohse, L. Osborne, X. Wang, M. Finegold, I.L.
Weissman, and M. Grompe. Purified
hematopoietic stem cells can differentiate to hepatocytes in vivo. Nature Medicine 6: 1229-1234, 2000.
Terskikh A., A. Fradkov, G. Ermakova, A. Zaraisky,
P. Tan, A.V. Kajava, X. Zhao, S.
Lukyanov, M. Matz, S. Kim, I. Weissman, and P. Siebert. “Fluorescent timer”: protein that changes color with
time. Science 290: 1585-1588, 2000.
Uchida N, D.W. Buck, H.
Dongping, M.J. Reitsma, M. Masek, T.V. Phan, A.S. Tsukamoto, F.H. Gage, and I.L. Weissman.
Direct isolation of human central nervous system stem cells. PNAS 97: 14720-14725, 2000.
Traver, D., K. Akashi, M. Manz,
M. Merad, T. Miyamoto, E.G. Engleman, and I.L. Weissman. Development of CD8a-positive dendritic
cells from a common myeloid progenitor.
Science 290: 2152-2154, 2000.
Shizuru, J.A., I.L. Weissman, R.
Kernoff, M. Masek, and Y.C. Scheffold.
Purified hematopoietic stem cell grafts induce tolerance to alloantigens
and can mediate positive and negative T cell selection. PNAS 97:9555-9560, 2000.
Domen. J., and I.L.
Weissman. Hematopoietic stem cells
need two signals to prevent apoptosis; BCL-2 can provide one of these,
Kitl/c-Kit signaling the other. J.
Exp. Med. 192: 1707-1718, 2000.
Wright, D.E., and I.L.
Weissman. Formation and
differentiation of leukocytes.
In: Physiology of
Inflammation. K. Ley, Ed., Oxford
Press, pp. 11-51, 2001.
Geschwind, D.H., J. Ou, M.C.
Easterday, J.D. Dougherty,R.L.
Jackson, Z. Chen, H. Antoine, A. Terskikh, I.L. Weissman, S.F. Nelson,
and H.I. Kornblum. A genetic
analysis of neural progenitor differentiation. Neuron 29: 325-339, 2001.
Kogan, S.C., D.E. Brown, D.B.
Schultz, B-TH. Truong, V. Lallemand-Breitenbach,M.-C. Guillemin, E. Lagasse, I.L. Weissman, and J.M. Bishop. BCL-2 cooperates with Promyelocytic
Leukemia Retinoic Acid Receptor (PMLRARa) to block neutrophil differentiation
and initiate acute leukemia. J.
Exp. Med. 193: 531-543, 2001.
Qian F, D. Hanahan, and I.L.
Weissman. L-selectin can
facilitate metastasis to lymph nodes in a transgenic mice model of
carcinogenesis. PNAS 98: 3976-3981, 2001.
Allsopp, R.C., S. Cheshier, I.L.
Weissman. Telomere shortening
accompanies increased cell cycle activity during serial transplantation of
hematopoietic stem cells. J. Exp. Med. 193:
917-924, 2001.
Akashi K, and I.L. Weissman. Stem cells and hematolymphoid
development. In: Hematopoiesis, A Developmental
Approach, Zon LI, editor, Oxford Press, pp 15-34, 2001.
Anderson, D.J., F.H. Gage, and
I.L. Weissman. Can stem cells
cross lineage boundaries? Invited commentary,
Nature Med. 7: 393-395, 2001.
Wright, DE, S. H. Cheshier, A.J.
Wagers, T.D. Randall, J.L. Christensen, and I.L. Weissman. Cyclophosphamide/ granulocyte
colony-stimulating factor causes selective mobilization of bone marrow
hematopoietic stem cells into the blood after M-phase of the cell cycle. Blood 97: 2278-2285, 2001.
Park I-K, C.A. Klug, K. Li, L.
Jerabek, L. Li, M. Nanamori, R. R. Neubig, L. Hood, I.L. Weissman, and M.F.
Clarke. Molecular cloning and
characterization of a novel regulator of G-protein signaling from mouse
hematopoietic stem cells. J. Biol.
Chem. 276: 915-923, 2001.
Lagasse E, J. A. Shizuru, N.
Uchida, A. Tsukamoto, and I.L. Weissman.
Towards regenerative medicine.
Immunity 14: 425-436, 2001.
Weissman I.L., and D. Baltimore. Disappearing stem cells, disappearing
science. Invited editorial,
Science 292: 601, 2001.
Manz, M.G., D. Traver, T.
Miyamoto, I.L. Weissman, and K. Akashi.
Dendritic cell potentials of early lymphoid and myeloid
progenitors. Blood 97: 3333-3341, 2001.
Mebius, R.E., T. Miyamoto, J.
Christensen, J. Domen, T. Cupedo,
I.L. Weissman, and K.
Akashi. The fetal liver
counterpart of adult common lymphoid progenitors gives rise to all lymphoid
lineages, CD45+ CD4+ CD3- cells, as well as
macrophages. J. Immunol. 166: 6593-6601, 2001.
Terskikh, A.V., M.C. Easterday, L.
Li, L. Hood, H.I. Kornblum, D.H. Geschwind, and I.L. Weissman. From hematopoiesis to
neuropoiesis: evidence of
overlapping genetic programs. PNAS
98: 7934-7939, 2001.
DiMartino, J.F., L. Selleri, D.
Traver, M.T. Firpo, J. Rhee, R. Warnke, S. O’Gorman, I.L.Weissman, and
M.L. Cleary. The Hox cofactor and
proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in
the fetal liver. Blood 98: 618-626, 2001.
Traver, D, T. Miyamoto, J.
Christensen, J. Iwasaki-Arai, K. Akashi, and I.L. Weissman. Fetal liver myelopoiesis occurs through
distinct, prospectively isolatable progenitor subsets. Blood 98: 627-635, 2001.
Yuan Y, L. Zhou, T. Miyamoto, H.
Iwasaki, N. Harakawa, C.J. Hetherington, S.A. Burel, E. Lagasse, I.L. Weissman,
K. Akashi, and D.-E. Zhang.
AML1-ETO expression is directly involved in the development of acute
myeloid leukemia in the presence of additional mutations. . PNAS 98: 10398-10403, 2001.
Kondo, M, D.C. Scherer, A.G. King,
M.G. Manz, and I. L. Weissman.
Lymphoycte development from hematopoietic stem cells. Invited review, Curr. Opinion in
Genetics & Development 11: 520-526,
2001.
Brown, J.M., I.L. Weissman, and
J.A. Shizuru. Immunity to
infections following hematopoietic cell transplantation. Current Topics Immunology, pp. 451-147,
2001.
Mebius, R.E., I.L. Weissman, and G.
Kraal. The development of the
lymph node vasculature. In: Morphogenesis of Endothelium. W Risau, Ed. In press.
Jerabek, L, and I.L.
Weissman. Intrathymic injection
for analysis of T cell progenitor activity. In:
Hematopoietic Stem Cell Protocols.
Klug CA, Jordan CT, Eds.
Humana Press. In press.
Weissman. I.L., D.J. Anderson,
and F. Gage. Stem and progenitor
cells: origins, phenotypes,
lineage commitments, and transdifferentiation. In: Annual
Review of Cell and Developmental Biology. In press.
Manz M.G., D. Traver, K. Akashi,
M. Merad, T. Miyamoto, E. Engleman, and I L. Weissman. Dendritic cell development from common
myeloid progenitors.
In: Hematopoietic Stem
Cells 2000: Basic and Clinical
Sciences - Third International Conference, Vol. 938 of the Annals of the New
York Academy of Science, Orlic D, Brummendorf TH, Sharkis SJ, and Kanz L, eds.
In press.
Reya T, S.J. Morrison, M.F.
Clarke, and I.L. Weissman. Stem
cells, cancer, and cancer stem cells.
Invited review, Nature. In
press.
Wagers, A.J., J.L. Christensen, and
I.L. Weissman. Cell fate
determination from stem cells.
Invited review, Gene Therapy. In press.
Park I-K, Y. He, F. Lin, O.D.
Laerum, Q. Tian, R. Bumgarner, C.A. Klug, K. Li, C. Kuhr, M.J. Doyle, Y. Sun, M. Schummer, A.
Goldsmith, M.F. Clarke, I.L. Weissman, L. Hood, and L. Linheng. Differential gene expression profiling
of adult murine hematopoietic stem cells.
Blood. In press.