Barres, Ben A. Developmental Biology Neurosciences
Our lab is interested in the neuronal-glial interactions that
underlie the development and function of the mammlian central
nervous system.
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Crabtree, Gerald R. Developmental
Biology Immunology
Signaling in the development of the nervous and immune systems. Chromatin
remodeling in development. Methods of producing conditional alleles using small
molecules.
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Fuller, Margaret T. Developmental Biology Genetics
Transcriptional and post transcriptional regulation of spermatogenesis;
Cell morphogenesis and cell cycle control during differentiation;
Genetic control of stem cell behavior.
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Hogness, David S. Biochemistry Developmental Biology
We wish to understand the mechanisms by which genes control development. We are studying two sorts of genetic regulatory hierarchies controlling development in Drosophila melanogaster. One of these specifies the segmentation pattern of the body plan along its anterior-posterior axis and includes the "homeotic" genes. The second kind of hierarchy
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Kaiser, A. Dale Biochemistry Cancer Biology Developmental Biology
How are genes regulated to construct a developmental program? How do signals received from other cells change the program and coordinate it for multicellular development? The approach taken by our laboratory group to answer these questions utilizes biochemistry and genetics; genetics to isolate mutants that have particular defects in development and biochemistry to determine the molecular basis of the defects. We study fruiting body development in Myxococcus xanthus, a social bacterium.
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Kim, Stuart K. Developmental Biology Genetics
We study cell polarity and MAP kinase signaling in C. elegans. We have found that a complex of PDZ-containing proteins is required for basolateral localization of the LET-23 receptor in epithelial cells. We have identified genes regulated by MAP kinase signaling using DNA microarrays.
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Kim, Seung K. Developmental Biology
We study morphogenesis and cell differentiation in the pancreas, an endoderm-derived organ, using molecular, embryologic and genetic methods in mice, chicks and human tissues. Our work suggests that critical epithelial-mesenchymal cell interactions during pancreas ontogeny are regulated by Hedgehog, FGF and TGF-ß signaling pathways. We wish to translate these basic studies into novel diagnostic and therapeutic strategies for diabetes mellitus and pancreas cancer.
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Kingsley, David M. Developmental Biology
My laboratory uses a variety of genetic, cellular, and molecular approaches to study skeletal development in humans, mice, and fish. Many of our studies begin with classical genetic traits that disrupt normal skeletal development. By isolating the genes responsible for these traits, it should be possible to identify the key genetic pathways that underlie skeletal patterning, skeletal disease, and skeletal evolution in higher animals.
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Nusse, Roeland Cancer Biology Developmental Biology
We are interested in the tole of the Wnt gene family in intercellular signaling during embryogenesis and tumorigenesis. We work on two Drosophila Wnt genes: wingless and DWnt-2. These genes have very specific phenotype in the fly. We use Drosophila genetics and cell culture assays to understand how these proteins work during embryogenesis. We have found that Frizzled proteins act as receptors for Wnts.
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Porzig, Ellen F. Developmental Biology Molecular Pharmacology
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Scott, Matthew P. Developmental Biology Genetics Neurosciences Cancer Biology
We study regulators of transcription and signaling that control animal development and prevent cancerous growth. Particular areas include homeobox genes, hedgehog/patched signaling and its links to skin and brain cancer, chromatin gene regulation machines, and neural and heart development.
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Shapiro, Lucille Cancer Biology Developmental Biology Genetics
A basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry. The developmental program by which a single cell proceeds to a fully-developed organism involves
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Spudich, James A. Biochemistry Biophysics Cancer Biology Developmental Biology
The general research interest of this laboratory is the molecular basis of cell motility. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and
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Talbot, William S. Developmental Biology
We use genetic and genomic approaches to investigate the molecular basis of cell fate specification and morphogenesis in the zebrafish embryo.
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Villeneuve, Anne M. Developmental Biology Genetics
Mechanisms underlying pairing and recombination between homologous chromosomes during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of meiotic chromosomes. Transgene-mediated cosuppression of germline gene expression.
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Weissman, Irving L. Cancer Biology Developmental Biology Immunology Biological Sciences
Development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis. |