Charles Prober

Charles Prober, Professor Pediatrics; Microbiology and Immunology Stanford University Medical Center, Stanford, CA 94305 Tel: (650) 723-5682 FAX: (650) 725-8040

Two distinct research interests relevant to the field Pediatric Infectious Diseases are represented in this program. First, there is a focus on the epidemiology, immunology, and management of herpes simplex virus (HSV) infections in pregnant women and their neonates. The laboratory component of this research involves defining the humoral and cellular immune responses to HSV in these hosts with attempts to relate these reponses to risk of infection and the development of strategies for prevention. The clinical component of this research involves defining the epidemiology of HSV-2 infections in pregnant women, their spouses, and neonates. The second broad research interest focuses on defining the pharmacokinetics of various antimicrobial agents in neonates, infants, and children.

Hardy, D.A., Arvin, A.M., Yasukawa, L.L., Lewinshon, D.M., Hensleigh, P.A., Prober, C.G.: The successful identification of asymptomatic genital infection with herpes simplex virus in pregnant women as delivery using the polymerase chain reaction. J Infect Dis 162:1031-1035, 1990.
Boucher, F.D., Yasukawa, L.L., Bronzan, R.N., Hensleigh, P.A., Arvin, A.M., Prober, C.G.: A prospective evaluation of primary genital herpes simplex virus type 2 infections acquired during pregnancy. Pediatr Infect Dis J 9:499-504, 1990.
Whitley, R.J., Arvin, A., Prober, C., et al.: A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection, N Engl J Med 324:444-449, 1991.
Smith, D.W., Frankel, L.R., Mathers, L.H., Tang, A.T.S., Ariagno, R.L., Prober, C.G. A double-blind placebo-controlled evaluation of aerosolized ribavirin in infants receiving mechanical ventilation for severe lower respiratory tract infections caused by respiratory syncytial virus. N Engl J Med 325:24-29, 1991.
Kulhanjian, J.A., Soroush, V., Au, D.S., Bronzan, R.N., Yasukawa, L.L., Weylman, L.E., Arvin, A.M., Prober, C.G. Identification of women at unsuspected risk of contracting primary herpes virus type 2 infections during pregnancy. N Engl J Med 326:916-920, 1992.
Boucher, F.D., Yasukawa, L.L., Kerns, et al. Detection of antibodies to herpes simplex virus type-2 with mammalian cell line expressing glycoprotein gb-2. Clin Diag Virol J 1:29-38, 1993.
Randolph, A.G., Washington, A.E., Prober, C.G. Cesarean delivery for women presenting with genital herpes lesions: risks, benefits and efficacy. JAMA 270:77-82, 1993.

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