|
Gene |
Regulating Compound |
Direction of Regulation (mRNA) |
Fold Change |
Direction of Regualtion (Protein) |
Fold Change |
Techniques |
Dose |
Time |
Medium |
Reference |
Notes |
| EGF |
R1881 (Synthetic Androgen) |
|
|
 |
16X (7 days) |
EGF Radioimmunassay |
1 nM |
2, 7 days |
RPMI + 10% Charcoal-Stripped FCS |
Prostate 26(6):290-298 |
Hydroxyflutamide blocks this induction. |
| EGFR (EGF Receptor) |
LHRH-A (Agonist) |
|
|
 |
Not Calculated |
Ligand Binding |
1 uM |
1.5-3 hours |
Not Reported |
Steroids
61(4):222-5 |
|
| EGFR (EGF Receptor) |
R1881 (Synthetic Androgen) |
|
|
|
4.5X (24 hours) |
Ligand Binding |
1 nM |
24, 72, 144 hours |
RPMI + 10% Charcoal-Stripped FCS |
Prostate 26(6):290-298 |
|