|
Regulating Compound |
Gene |
Direction of Regulation (mRNA) |
Fold Change |
Direction of Regualtion (Protein) |
Fold Change |
Techniques |
Dose |
Time |
Medium |
Reference |
Notes |
| TNF alpha |
AR (Androgen Receptor) |
No Change (Not Expressed) |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
c-myc |
No Change |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
CD-44 |
|
|
No Change (Not Expressed) |
|
FACS |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
Collagenase (Type IV) |
No Change |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
E-cadherin |
No Change |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
EGFR |
No Change |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
FGF2 (basic) |
 |
2X |
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
Her-2 |
No Change |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
HLA Class I Antigen |
|
|
No Change |
|
FACS |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
HLA Class II Antigen |
|
|
No Change |
|
FACS |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
ICAM-1 |
|
|
No Change |
|
FACS |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
IL-6 |
No Change |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
Integrin alpha3 |
|
|
 |
1.7X |
FACS |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
Integrin Beta1 |
|
|
No Change |
|
FACS |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
P-cadherin |
 |
2.5X |
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
PSA (Prostate-Specific Antigen) |
No Change (Not Expressed) |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
PSM (Prostate-Specific Membrane) |
No Change (Not Expressed) |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| TNF alpha |
TGF beta |
No Change |
|
|
|
RT-PCR |
200 U/mL |
48 H |
RPMI-1640 + 10% FBS |
Cancer 77(9): 1862-72 |
at 80-90% confluence |
| troglitazone |
CD36 (oxidized LDL R) |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone |
E-cadherin |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone |
PPARgamma |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone, all-trans-retinoic
acid |
CD36 (oxidized LDL R) |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM/100 nM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone, all-trans-retinoic
acid |
E-cadherin |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM/100 nM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone, all-trans-retinoic
acid |
PPARgamma |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM/100 nM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone, LG100268 |
CD36 (oxidized LDL R) |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM/100 nM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone, LG100268 |
E-cadherin |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM/100 nM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|
| troglitazone, LG100268 |
PPARgamma |
|
|
No Change |
None |
Western, Immunohistochemistry |
10 uM/100 nM |
4 days |
DMEM + 10% FCS |
Cancer Res 58(15): 3344-52 |
|