Molecular and cellular biology of lymphocyte and neutrophil homing. Cell adhesion in immune responses.
Contribution of T-cells to immunocompetence and autoimmnity. T-cell recognition and differentiation.
Characterization of T-cell response to transplantation antigens: induction of tolerance, mechanisms of immune regulation.
Chromosomal translocations and protooncogenes in leukemia and lymphoma.
Genetic regulatory mechanisms in T-lymphocyte activation; expression of the IL-2 gene.
Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes.
Human T-cells, NK cells, monocytes, and dendritic cells: functional proteins and genes; immunobiology of AIDS.
Structure-function relationships of T-cell receptor MHC-restricted antigen recognition; mechanisms of autoimmunity.
Ion channel regulation and function in T and B lymphocytes using techniques including patch clamp and flurometric analysis.
HLA antigens and genes: polymorphisms, secretion, tolerogenesis, and disease associations.
Leo
Gene regulation; molecular immunology; fluorescence-activated cell-sorting; AIDS.
Molecular mechanisms; regulation of B-cell development
Origin and functional significance of MHC polymorphism TCR-peptide-MHC interactions; molecular regulation of MHC antigen expression.
Human cytolytic T-lymphocyte interactions with transplants and tumors; T-cell-specific genes.
Immunology and molecular biology of lymphoid malignancy; somatic mutation of antibody genes.
Mechanisms of calcium signaling in T-lymphocyte activation, including functional roles of ion channels and intracellular calcium.
Mechanism and regulation of the site-directed recombinases (VDJ recombinase and class-switch recombination activity) and the site-directed hypermutation activity of affinity maturation.
Molecular basis of leukemias; hematopoiesis myb oncogene.
Physical chemistry of antigen presentation; reconstituted membrane systems.
Analysis of the role of MHL molecules in self-tolerance and in autoimmunity.
Utilization of tissue - specific derivatives of histamine as immune modulators.
Department of Medicine/ Hematology. Bone marrrow transplantation biology of cytokine induced killer cells; mechanism of killer cell recognition of targets; minimal residual disease detection in bone marrow.
Studying signal transduction in lymphocytes; tumor immunology and immunotherapy.
Biochemical Genetics of NF-kB and how it relates to signaling in B and T cells. Regulation of Bcl-3, p50, and related factors in the immune system and how HIV uses them for its own regulations. High titre retroviral delivery systems.
Role of MHC Class I molecules in presenting antigens to cytotoxic T-lymphocytes; mechanisms of intracellular transport via clathrin-coated vesicles.
Molecular genetics, regulation, and function of T- and B-lymphocyte differentiation antigens, e.g. CD4 and CD8; T- and B-cell activation.
Cellular and molecular mechanisms of immune reactions in the central nervous system, particularly in multiple sclerosis.
Development of immune therapy for autoimmune disease.
Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation.
Heterogeneity among human and murine CD4+ helper/inducer T-cells: activation requirements, development, interactions with other lymphoid cells, and role in allergic disease.
Application of antibodies for diagnosis and classification of human lymphomas, including tumor-host relationships.
Developmental biology of the immune system, including analysis of hematopoietic stem cells, T-cell differentiation, lymphocyte homing receptors and killer T-cell genes.