Lena Ho, Raja Jothi, Jehnna L. Ronan, Kairong Cui, Keji Zhao, Gerald R. Crabtree, An Embryonic Stem Cell Chromatin Remodeling Complex, esBAF is an Essential Component of the Core Pluripotency Transcriptional Network PNAS in press 2009
Lena Ho, Jehnna L. Ronan, Jiang Wu, Brett Staahl, Lei Chen, Ann Kuo, Julie Lessard, Alexey I. Nesvizhskii,
Jeff Ranish, and Gerald R. Crabtree, An embryonic stem cell chromatin remodelingcomplex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency PNAS in press 2009
Jiang Wu, Julie Lessard and Gerald R. Crabtree; Understanding the Words of Chromatin Regulation Cell Jan 23 2009
Shih-Chu Kao, Hai Wu, Jianming Xie, Ching-Pin Chang, Jeffrey A. Ranish, Isabella A. Graef, and Gerald R. Crabtree; Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation Science Jan 30 2009
Elena M Gallo, Ho L, Winslow MM, Staton TL, Crabtree GR.Selective role of calcineurin in haematopoiesis and lymphopoiesis.
EMBO Rep. 2008 PMID: 18818667
Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L, Iritani B, Neilson JR, Crabtree GR. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature 450, 731-5 (2007).
Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55, 201-15 (2007).
Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR. Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56, 94-108 (2007).
Liu, K. J., Arron, J. R., Stankunas, K., Crabtree, G. R. & Longaker, M. T. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature 446, 79-82 (2007).
Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature 443, 345-9 (2006).
Jiang I. Wu and Gerald R. Crabtree Nuclear Actin as Choreographer of Cell Morphology and Transcription Science 22 June 2007 316: 1710-1711 PMID: 17588921
Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441, 595-600 (2006).
Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chem Biol. 2006 Jan;13(1):99-107. PMID: 16426976
Winslow MM, Pan M, Starbuck M, Gallo EM, Deng L, Karsenty G, Crabtree GR. Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell. 2006 Jun;10(6):771-82.
Winslow MM, Gallo EM, Neilson JR, Crabtree GR. The calcineurin phosphatase complex modulates immunogenic B cell responses.
Immunity. 2006 Feb;24(2):141-52
Winslow MM, Crabtree GR. Immunology. Decoding calcium signaling. Science. 2005 Jan 7;307(5706):56-7. PMID: 15637261
Gestwicki J,
Crabtree GR and Graef IA Harnessing Chaperones to Generate Potent
Small Molecule Inhibitors of Amyloid Aggregation. Science, Oct
29, 2004 p 865-869, PDF or HTML For
information from the popular press see BBC
News, or Scientific
American (PDF),
or CNN
News (PDF),
or Chemical Engineering
News, or HHMI Report,
or ABC
News
Chang, CP, Neilson, J.R. Bayle, J.H.,
Gestwicki, J.E., Kuo, a. Stankunas,
K. Graef,
IA and Crabtree G.R. A Field of Calcineurin-NFAT
signaling underlies heart valve morphogenesis, Cell Sept
3rd 2004. Note the cover design and the accompanying editorial. PDF or HTLM for the paper, PDF or HTML for the Editorial
Neilson JR, Winslow MM, Hur EM, Crabtree GR.
Calcineurin B1 is essential for positive but not negative selection
during thymocyte development. Immunity. 2004 Mar;20(3):255-66.
Stankunas et al. Condtional Protein
Alleles Using Knock-in Mice and a Chemical Inducer of Dimerization Mol Cell Dec 12, 1615-1624, 2003.HTML PDF
Graef I.A. et al Neurotrophins
and netrins require calcineurin/NFAT signaling
to stimulate outgrowth
of embryonic
axons.Cell. 2003 May 30;113(5):657-70. HTML PDF
Chi et al.Reciprocal regulation of CD4/CD8 expression
by SWI/SNF-like BAF complexes.Nature.
2002 Jul 11;418(6894):195-9. HTML PDF
Bayle et. al. Hyperphenylalaninemia and impaired
glucose tolerance in mice lacking the bifunctional DCoH gene.J Biol Chem. 2002 Aug 9;277(32):28884-91HTML
Rando OJ, et al. Phosphatidylinositol-dependent
actin filament binding by the SWI/SNF-like BAF chromatin remodeling
complex.Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2824-9. HTML
Graef IA, et al. Signals transduced by Ca(2+)/calcineurin
and NFATc3/c4 pattern the developing vasculature.Cell. 2001
Jun 29;105(7):863-75 HTML PDF
Graef IA, et al. L-type calcium channels and GSK-3
regulate the activity of NF-ATc4 in hippocampal
neurons.Nature. 1999 Oct 14;401(6754):703-8 HTML PDF |