Khavari Lab: Selected Publications

Mendel DB, Khavari PA, Conley PB, Graves MK, Hansen LP, Admon A. and Crabtree GR. Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Science 254:1762, 1991.

Khavari PA, Peterson CL, Tamkun JW, Mendel DB, and Crabtree GR. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature 366:170, 1993.

Dunaief JL, Strober BE, Sushovan G, Khavari PA, Alin K, Luban J, Bergmann M, Crabtree GR, Goff SP. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79:1, 1994.

Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR. Nucleosome disruption and enhancement of activator binding by a human SWI/SNF complex. Nature 370:477-481, 1994.

Choate KA, Medalie DA, Morgan JR and Khavari PA. Corrective gene transfer in the human skin disorder in lamellar ichthyosis. Nature Medicine 2:1263-1267, 1996.

Blau HM and Khavari PA. Gene therapy: Progress, problems and prospects. Nature Medicine 3:612-613, 1997.

Fan H, Oro AE, Scott MP and Khavari PA. Induction of basal cell carcinoma features in transgenic human skin expressing sonic hedgehog. Nature Medicine 3:788-792, 1997.

Deng H, Lin Q and Khavari PA. Sustainable cutaneous gene delivery. Nature Biotechnology 15:1388-1391, 1997.

Seitz CS, Lin Q, Deng H and Khavari PA. Alterations in NF-kB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kB. Proceedings of the National Academy of Sciences U.S.A. 95:2307-2312, 1998.

Fan H, Morrissey GR, Lin Q and Khavari PA. Genetic immunization by topical application of naked DNA to normal skin. Nature Biotechnology 17:870-872, 1999.

Fan H and Khavari PA. Sonic hedgehog opposes epithelial cell cycle arrest. Journal of Cell Biology 147:71-76, 1999.

Rothbard JB, Garlington S, Lin Q, McGrane PL, Wender PA and Khavari PA. Conjugation of oligoarginine to cyclosporin A facilitates topical delivery and inhibition of inflammation. Nature Medicine 6:1253-1257, 2000.

Robbins PB, Lin Q, Goodnough JB, Tian H, Chen X and Khavari PA. In vivo restoration of laminin 5 b3 expression and function in junctional epidermolysis bullosa. Proceedings of the National Academy of Sciences U.S.A. 98:5193-5198, 2001.

Lazarov M, Kubo Y, Dajee M, Tarutani M, Lin Q, Tao S, Green CL and Khavari PA. CDK4 co-expression with Ras generates malignant human epidermal tumorigenesis. Nature Medicine 8:1105-1114, 2002.

Cai T, Nishida K, Hirano T and Khavari PA. Gab1 and SHP-2 Promote Ras/MAPK regulation of epidermal growth and differentiation. Journal of Cell Biology 159:103-112, 2002.

Ortiz-Urda S, Thyagarajan B, Keene, D, Lin Q, Fang M, Calos MP and Khavari PA. Nonviral genetic correction of inherited human skin disease using the phiC31 integrase. Nature Medicine 8:166-1170, 2002.

Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ, Marinkovich MP, Tao S, Lin Q, Kubo Y and Khavari PA. NF-kB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421: 639-643, 2003.

Zhang JY, Green CL, Tao S and Khavari PA. NF-kB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes & Development 18:17-22, 2004.

Khavari PA. Profiling epithelial stem cells. Nature Biotechnology 22:393-394, 2004.

Zhang JY, Tao S, Kimmel R and Khavari PA. CDK4 regulation by TNFR1 and JNK is required for NF-kB-mediated growth control. Journal of Cell Biology 168:561-566, 2005.

Chudnovsky Y, Adams AE, Robbins PB, Lin Q and Khavari PA. Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Nature Genetics 37:745-749, 2005.

Ortiz-Urda S, Garcia J, Green CL, Chen L, Lin Q, Veitch DP, Sakai LY, Lee H, Marinkovich MP and Khavari PA. Type VII collagen is required for human epidermal tumorigenesis. Science 307:1773-1776, 2005.

Khavari PA. Modeling cancer in human skin tissue. Nature Reviews Cancer 6:270-280, 2006.

Adams AE, Chudnovsky Y, and Khavari PA. Oxygen deprivation provokes melanoma. Nature Medicine 112:168-169, 2006.

Truong AB, Kretz M, Ridky TW, Kimmel R and Khavari PA. p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes & Development 20:3185-3187, 2006.

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