Readings:

There are two types of reading for this course: Background and Recommended & Required Readings. The readings have been split into sections that coincide with the syllabus below. Lecturers will indicate which readings are required in class. 

Please check this site periodically as the readings will be updated continuesly based on the interests of the class and the directions taken by the lecturers.

I. Introduction to Thermodynamics & Molecular Forces

Background Reading:

1. Chapter 8 in Biochemistry, Abeles, Frey and Jencks.

Recommended/Required Reading:

1. Physical Chemistry: Principles and Applications in Biological Sciences (4th Edition) Ignacio Tinoco, Kenneth Sauer, James C. Wang, Joseph D. Puglisi, 06 August, 2001, ISBN: 013095943X.
2. Biophysical Chemistry Part III: The Behavior of Biological Macromolecules, Charles R. Cantor, Paul Reinhart Schimmel.
3. Physical Chemistry, Eisengberg and Crothers.
4. Physical Biochemistry. K. E. Van Holde.

II. Protein Structure

Background Reading:

1. Proteins: Structures and Molecular Properties, Creighton.
2. Or an understanding of the basics of amino acids, polypeptides and protein structure as decribed in a standard undergraduate texts on biochemistry.

Recommended/Required Reading:

None.

III. Protein-Protein Interactions & Applications

Background Reading:

None.

Recommended/Required Reading:

1. Janin J. (1997) "Angstroms and calories". Structure. Apr 15;5(4):473-9.
2. Wells JA. (1996) "Binding in the growth hormone receptor complex." Proc Natl Acad Sci U S A. Jan 9;93(1):1-6.

IV. Allostery/Molecular transducers

Background Reading:

1. Chapters 1-6 (pp. 5-94) in Random Walks in Biology, Berg.

Recommended/Required Reading:

1. Chapters 1-6 (pp. 5-94) in Random Walks in Biology, Berg.

V. Rates of Biological Processes

A. Diffusion and Biology

Background Reading:

1. Chapters 1-6 (pp. 5-94) in Random Walks in Biology, Berg

Recommended/Required Reading:

1. Chapters 1-6 (pp. 5-94) in Random Walks in Biology, Berg

 

B. Enzymes: Basic concepts of kinetics, catalysis & energetics

Background Reading:

1. Chapter 3 in Biochemistry, Abeles, Frey and Jencks.
2. Biochemical Calculations, 2nd Ed., Irwin H. Segel (pp. 208-245).

Recommended/Required Reading:

1. Chapters 4 & 5 in Biochemistry, Abeles, Frey and Jencks.

VI. Biochemical Approaches

Background Reading:

1. Chapters 5 & 6 & pp. 246-319 in Biochemical Calculations, 2nd Ed., Irwin H. Segel.
2. Physical Biochemistry (Prentice-Hall's Foundations of Modern Biochemistry Series), Kensal Edward Van Holde. (book is out of print)

Recommended/Required Reading:

None. 

VII. Special Topics: Kinetic Simulation Workshop

Background Reading:

None.

Recommended/Required Reading:

None.

VIII.Single Molecule Approaches

Background Reading:

None.

Recommended/Required Reading:

None.

 Last updated 9/25/03